It is important to talk about any history of heart disease with your healthcare provider before using PPIs. This is because some PPIs can reduce the function of the blood thinner. Additionally, those who have had a heart attack and are on blood thinners like clopidogrel (Plavix), can have a repeat heart attack. It is not clear why this may happen, but studies suggest that PPI use may increase this risk. Increased chance of heart attack(s): Using PPIs for long periods of time (many months to years) may increase the risk of a heart attack.If caught early, the condition can be treated and leave no signs of damage to your kidneys. Using PPIs may increase the risk of developing acute interstitial nephritis. Swelling of the inside of your kidney can cause damage, and, if left untreated, can cause serious health problems. This usually happens due to an allergic reaction, typically to medicines you may be taking, like PPIs. Acute interstitial nephritis: This is a condition that causes swelling of the inside of the kidney.Studies did not include individuals who currently have kidney disease, so it is not clear if PPI use can make kidney disease worse. This does not mean that everyone who uses PPIs will get chronic kidney disease, but it is important to know that there may be a risk. Increased chance of chronic kidney disease: It has not been proven that PPI use causes chronic kidney disease, but some studies suggest there is an increased risk of chronic kidney disease in individuals who have normal kidney function before using a PPI.Here are some risks and issues that have occurred in some people: As with any medication, you should consider both the benefits and risks. It is important to go over these with your healthcare provider to make sure this is the best type of care for your symptoms. But depending on your overall health and how long you have to take your PPI medication, there can be different health concerns and side-effects. PPIs are considered safe and effective in most people.
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